Standard Name	SAS2 1
Systematic Name	YMR127C
Feature Type	ORF, Verified
Description	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family (2, 3)
Name Description	Something About Silencing 4
Gene Product Alias	KAT8 5

Chromosomal Location	ChrXIII:523345 to 522329 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SAS2
Molecular Function
Manually curated	acetyltransferase activity (IDA) histone acetyltransferase activity (IDA)
Biological Process
Manually curated	chromatin silencing at telomere (IDA) histone acetylation (IMP) histone exchange (IMP)
Cellular Component
Manually curated	nuclear chromatin (IDA) nuclear chromosome, telomeric region (IC) SAS acetyltransferase complex (IDA, IPI)

Classical genetics
null	replicative lifespan: increased resistance to arsenite(3-): decreased silencing: increased
Large-scale survey
null	competitive fitness: increased resistance to dimethyl sulfoxide: decreased vacuolar morphology: abnormal viable
overexpression	silencing: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	149 total interaction(s) for 84 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-Western: 12 Co-fractionation: 2 Co-localization: 5 Reconstituted Complex: 4 Two-hybrid: 6
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 1 Negative Genetic: 43 Phenotypic Enhancement: 7 Phenotypic Suppression: 1 Positive Genetic: 9 Synthetic Growth Defect: 24 Synthetic Lethality: 4 Synthetic Rescue: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:523345 to 522329 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1017 523345..522329 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004734