Standard Name	SAM3
Systematic Name	YPL274W
Feature Type	ORF, Verified
Description	High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p (1)
Name Description	S-AdenosylMethionine metabolism

Chromosomal Location	ChrXVI:22938 to 24701 | ORF Map | GBrowse

	View Computational GO annotations for SAM3
Molecular Function
Manually curated	putrescine transmembrane transporter activity (IDA, IMP) S-adenosyl-L-methionine transmembrane transporter activity (IMP, ISS) spermidine transmembrane transporter activity (IDA, IMP)
Biological Process
Manually curated	putrescine transport (IDA, IMP) S-adenosyl-L-methionine transport (IMP) spermidine transport (IDA, IMP)
Cellular Component
Manually curated	plasma membrane (IDA, IMP, ISS)
High-throughput	integral to membrane (ISM)

Classical genetics
null	nutrient uptake: decreased resistance to Sinefungin: increased resistance to sinefungin: increased utilization of sulfur source: decreased
overexpression	nutrient uptake: increased resistance to sinefungin: decreased
reduction of function	resistance to sinefungin: increased resistance to Sinefungin: increased utilization of sulfur source: decreased
Large-scale survey
null	competitive fitness: decreased resistance to benzo[a]pyrene: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	56 total interaction(s) for 48 unique genes/features.
Physical Interactions	PCA: 22
Genetic Interactions	Negative Genetic: 29 Positive Genetic: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:22938 to 24701 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1764 22938..24701 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T73 S.c. Strain Vin13 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000006195