Standard Name	SAK1 1, 2 (see Nomenclature conflict Note)
Systematic Name	YER129W
Alias	PAK1 3
Feature Type	ORF, Verified
Description	Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication (1, 3, 4, 5, 6, 7)
Name Description	Snf1 Activating Kinase 1

Chromosomal Location	ChrV:417281 to 420709 | ORF Map | GBrowse

	View Computational GO annotations for SAK1
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA, IMP)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	DNA-dependent DNA replication (IGI) glucose metabolic process (IGI, IMP) protein phosphorylation (IDA, IGI, IMP)
High-throughput	protein phosphorylation (IDA)
Cellular Component
High-throughput	cytoplasm (IDA)

Classical genetics
null	dessication resistance: decreased Snf1p activity: decreased resistance to caffeine: decreased
overexpression	Mth1p accumulation: increased Std1p accumulation: increased
Large-scale survey
null	auxotrophy competitive fitness: increased dessication resistance: decreased resistance to fenpropimorph: increased resistance to camptothecin: increased resistance to cycloheximide: increased resistance to hydroxyurea: increased resistance to tunicamycin: increased vacuolar morphology: abnormal vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	100 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-MS: 29 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 Biochemical Activity: 6 Co-fractionation: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 2 Negative Genetic: 28 Phenotypic Enhancement: 1 Phenotypic Suppression: 3 Positive Genetic: 3 Synthetic Growth Defect: 10 Synthetic Lethality: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:417281 to 420709 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3429 417281..420709 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000931