SAH1/YER043C Summary

SAH1 BASIC INFORMATION

Standard Name	SAH1
Systematic Name	YER043C
Feature Type	ORF, Verified
Description	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor (1, 2, 3)
Name Description	S-Adenosyl-l-Homocysteine hydrolase

GO Annotations	All SAH1 GO evidence and references
	View Computational GO annotations for SAH1
Molecular Function
Manually curated	adenosylhomocysteinase activity (ISS)
Biological Process
Manually curated	methionine metabolic process (NAS) selenocysteine metabolic process (NAS)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	S-adenosylmethionine cycle

Mutant Phenotype	All SAH1 Phenotype details and references
Large-scale survey
null	inviable vegetative growth: decreased

Interactions	SAH1 All interactions details and references
	22 total interaction(s) for 21 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Two-hybrid: 2
Genetic Interactions	Synthetic Lethality: 1

Sequence Information

ChrV:237118 to 235769 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1350	237118..235769	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000845

SAH1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SAH1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SAH1]

1)	Shevchenko A, et al. (1996) Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Proc Natl Acad Sci U S A 93(25):14440-5
2)	Kanehisa M, et al. (2002) The KEGG databases at GenomeNet. Nucleic Acids Res 30(1):42-6
3)	Tehlivets O, et al. (2004) S-adenosyl-L-homocysteine hydrolase in yeast: key enzyme of methylation metabolism and coordinated regulation with phospholipid synthesis. FEBS Lett 577(3):501-6

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