ARG2/YJL071W Summary 
| Standard Name | ARG2 |
|---|---|
| Systematic Name | YJL071W |
| Alias | HRB574 |
| Feature Type | ORF, Verified |
| Description | Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p (1 and see Summary Paragraph) |
| Name Description | ARGinine requiring |
| Chromosomal Location | |
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Gene Ontology Annotations All ARG2 GO evidence and references
| View Computational GO annotations for ARG2 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
| Pathways |
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Mutant phenotypes All ARG2 Phenotype evidence and references
| Classical genetics | |
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| null |
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| overexpression | |
| Large-scale survey | |
| null |
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| Resources |
interactions All ARG2 Interaction evidence and references
| 22 total interaction(s) for 14 unique genes/features. | |
| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All ARG2 Protein evidence and references
| Localization | |
|---|---|
| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||
Analyze Sequence
| S288C only | |
|---|---|
| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000003607 |
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SUMMARY PARAGRAPH for ARG2
ARG2 encodes glutamate N-acetyltransferase (also called acetylglutamate synthase), which catalyzes the first step in the biosynthesis of ornithine, an intermediate in arginine biosynthesis (2). Like other ornithine biosynthetic enzymes, Arg2p is localized in the mitochondrial matrix (2). ARG2 transcription is repressed in the presence of arginine and is also regulated by glucose repression and general amino acid control (3, 4). Arginine-responsive transcription factors, including Arg80p, Arg81p, Arg82p, and Mcm1p, and their target upstream activating sequences in ARG2, have been identified (5, 6, 4).
Last updated: 1999-10-15 
References cited on this page View Complete Literature Guide for ARG2
| 1) | Abadjieva A, et al. (2001) A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase. J Biol Chem 276(46):42869-80 |
| 2) | Jauniaux JC, et al. (1978) Arginine metabolism in Saccharomyces cerevisiae: subcellular localization of the enzymes. J Bacteriol 133(3):1096-1107 |
| 3) | Wipe B and Leisinger T (1979) Regulation of activity and synthesis of N-acetylglutamate synthase from Saccharomyces cerevisiae. J Bacteriol 140(3):874-80 |
| 4) | Hinnebusch A (1992) "General and Pathway-specific Regulatory Mechanisms Controlling the Synthesis of Amino Acid Biosynthetic Enzymes in Saccharomyces cerevisiae". Pp. 319-414 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
| 5) | Messenguy F (1987) Multiplicity of regulatory mechanisms controlling amino acid biosynthesis in Saccharomyces cerevisiae. Microbiol Sci 4(5):150-3 |
| 6) | Messenguy F and Dubois E (1993) Genetic evidence for a role for MCM1 in the regulation of arginine metabolism in Saccharomyces cerevisiae. Mol Cell Biol 13(4):2586-92 |
