RRP14/YKL082C Summary

RRP14 BASIC INFORMATION

Standard Name	RRP14 1
Systematic Name	YKL082C
Feature Type	ORF, Verified
Description	Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family (1, 2, 3, 4)
Name Description	Ribosomal RNA Processing

GO Annotations	All RRP14 GO evidence and references
	View Computational GO annotations for RRP14
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ribosomal large subunit biogenesis (IMP, IPI) ribosomal small subunit biogenesis (IMP)
Cellular Component
Manually curated	colocalizes_with cytosolic large ribosomal subunit (IDA) nucleolus (IDA)

Mutant Phenotype	All RRP14 Phenotype details and references
Classical genetics
null	budding pattern: abnormal growth in exponential phase: decreased rate actin distribution: abnormal viable
repressible	35S pre-rRNA accumulation: decreased mature 25S rRNA accumulation: decreased mature 18S rRNA accumulation: decreased cell cycle progression through the G2/M phase transition: abnormal
Large-scale survey
null	inviable

Interactions	RRP14 All interactions details and references
	27 total interaction(s) for 21 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Two-hybrid: 17
Genetic Interactions	Synthetic Lethality: 1

Sequence Information

ChrXI:281973 to 280669 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-12-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1305	281973..280669	2005-12-15	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001565

RRP14 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RRP14

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RRP14]

1)	Polzikov M, et al. (2005) Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast. Biochem Biophys Res Commun 327(1):143-9
2)	Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71
3)	Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65
4)	Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27

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