HOS4/YIL112W Summary

HOS4 BASIC INFORMATION

Standard Name	HOS4 1
Systematic Name	YIL112W
Feature Type	ORF, Verified
Description	Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate (1, 2, 3)
Name Description	Hda One Similar 1

GO Annotations	All HOS4 GO evidence and references
	View Computational GO annotations for HOS4
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	histone deacetylation (IDA) negative regulation of meiosis (IPI)
Cellular Component
Manually curated	Set3 complex (IDA)

Mutant Phenotype	All HOS4 Phenotype details and references
Classical genetics
null	histone H3 modification: increased
Large-scale survey
null	glycogen accumulation: increased filamentous growth: decreased invasive growth: absent viable

Interactions	HOS4 All interactions details and references
	81 total interaction(s) for 46 unique genes/features.
Physical Interactions	Affinity Capture-MS: 35 Affinity Capture-Western: 3 Biochemical Activity: 6 Two-hybrid: 2
Genetic Interactions	Phenotypic Enhancement: 11 Phenotypic Suppression: 9 Synthetic Growth Defect: 3 Synthetic Lethality: 11 Synthetic Rescue: 1

Sequence Information

ChrIX:151592 to 154843 | |

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3252	151592..154843	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001374

HOS4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HOS4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HOS4]

1)	Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
2)	Pijnappel WW, et al. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004
3)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64

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