RLF2/YPR018W Summary Help

RLF2 BASIC INFORMATION

Standard Name RLF2 1
Systematic Name YPR018W
Alias CAC1 2
Feature Type ORF, Verified
Description Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin (3, 4)
Name Description Rap1 protein Localization Factor 1
GO Annotations All RLF2 GO evidence and references
    View Computational GO annotations for RLF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All RLF2 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions RLF2 All interactions details and references
187 total interaction(s) for 107 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-Western: 14
  • Biochemical Activity: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 25
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 59
  • Phenotypic Suppression: 10
  • Synthetic Growth Defect: 48
  • Synthetic Lethality: 8
  • Synthetic Rescue: 8
Sequence Information
ChrXVI:594473 to 596293 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-21 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1821 594473..596293 2004-07-21 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000006222

RLF2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for RLF2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RLF2]

1) Enomoto S, et al.  (1997) RLF2, a subunit of yeast chromatin assembly factor-I, is required for telomeric chromatin function in vivo. Genes Dev 11(3):358-70
2) Kaufman PD, et al.  (1997) Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. Genes Dev 11(3):345-57
3) Glowczewski L, et al.  (2004) Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus. Mol Cell Biol 24(23):10180-92
4) Adams CR and Kamakaka RT  (1999) Chromatin assembly: biochemical identities and genetic redundancy. Curr Opin Genet Dev 9(2):185-90