Standard Name	CUP9
Systematic Name	YPL177C
Feature Type	ORF, Verified
Description	Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)

Chromosomal Location	ChrXVI:213962 to 213042 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CUP9
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II repressing transcription factor binding (IPI) sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity (IC)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter (IMP) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	nucleus (IC)

Binding motifs	ATGTGTCA 6 [Search intergenic regions for ATGTGTCA] WWTRTGTCA 7 [Search intergenic regions for WWTRTGTCA]
Regulatory modules	predicted: stressResponse (421)
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	PTR2 mRNA accumulation: increased metal resistance: decreased Ptr2p-GFP accumulation: increased small molecule transport: increased viable
Large-scale survey
null	auxotrophy competitive fitness: decreased lifespan: increased nutrient utilization: increased toxin resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	85 total interaction(s) for 68 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 3 Reconstituted Complex: 3
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 69 Phenotypic Suppression: 1 Synthetic Growth Defect: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:213962 to 213042 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..921 213962..213042 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006098