Standard Name	TUF1 (see Nomenclature conflict Note)
Systematic Name	YOR187W
Feature Type	ORF, Verified
Description	Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans (1, 2) Also known as: tufM 1

Chromosomal Location	ChrXV:684030 to 685343 | ORF Map | GBrowse

	View Computational GO annotations for TUF1
Molecular Function
Manually curated	GTPase activity (IDA, IGI) translation elongation factor activity (IDA, IGI, ISS)
Biological Process
Manually curated	mitochondrial translation (IGI) mitochondrial translational elongation (ISA)
Cellular Component
Manually curated	mitochondrial matrix (ISS)
High-throughput	mitochondrion (IDA)

Classical genetics
null	mitochondrial rho- mutation frequency: increased respiratory growth: absent
reduction of function	respiratory growth: decreased
Large-scale survey
null	cell size: decreased polyphosphate accumulation: abnormal competitive fitness: decreased metal resistance: increased mitochondrial morphology: abnormal resistance to CTBT: decreased resistance to ethanol: decreased resistance to nickel sulfate: increased resistance to wortmannin: increased resistance to sirolimus: increased resistance to quinine: decreased resistance to 2,4-dichlorophenol: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased respiratory growth: decreased rate respiratory growth: absent vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	67 total interaction(s) for 66 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 1 Biochemical Activity: 2 PCA: 2
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 24 Positive Genetic: 23 Synthetic Growth Defect: 3 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:684030 to 685343 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1314 684030..685343 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005713