IRC21/YMR073C Summary

IRC21 BASIC INFORMATION

Standard Name	IRC21 1
Systematic Name	YMR073C
Feature Type	ORF, Verified
Description	Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52p foci (1, 2)
Name Description	Increased Recombination Centers 1

GO Annotations	All IRC21 GO evidence and references
	View Computational GO annotations for IRC21
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
High-throughput	response to drug (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All IRC21 Phenotype details and references
Large-scale survey
null	competitive fitness: decreased Rad52-YFP distribution: increased resistance to rapamycin: increased resistance to wortmannin: increased viable
overexpression	vegetative growth: decreased

Interactions	IRC21 All interactions details and references
	8 total interaction(s) for 8 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1
Genetic Interactions	Synthetic Growth Defect: 4 Synthetic Lethality: 3

Sequence Information

ChrXIII:412872 to 412267 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..606	412872..412267	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004677

IRC21 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for IRC21

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IRC21]

1)	Alvaro D, et al. (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228
2)	Lee W, et al. (2005) Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. PLoS Genet 1(2):e24

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.