FAR3/YMR052W Summary Help

Standard Name FAR3 1
Systematic Name YMR052W
Feature Type ORF, Verified
Description Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress (2, 3, 4)
Name Description Factor ARrest 5
Chromosomal Location
ChrXIII:379586 to 380200 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All FAR3 GO evidence and references
  View Computational GO annotations for FAR3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
219 total interaction(s) for 145 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • PCA: 1
  • Two-hybrid: 26

Genetic Interactions
  • Dosage Lethality: 2
  • Negative Genetic: 153
  • Phenotypic Enhancement: 3
  • Positive Genetic: 20
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 4
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 204
Molecular Weight (Da) 24,032
Isoelectric Point (pI) 8.36
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:379586 to 380200 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..615 379586..380200 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004656
References cited on this page View Complete Literature Guide for FAR3
1) Horecka J and Sprague GF Jr  (1996) Identification and characterization of FAR3, a gene required for pheromone-mediated G1 arrest in Saccharomyces cerevisiae. Genetics 144(3):905-21
2) Beilharz T, et al.  (2003) Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae. J Biol Chem 278(10):8219-23
3) Kemp HA and Sprague Jr GF Jr  (2003) Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Mol Cell Biol 23(5):1750-63
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Chang F and Herskowitz I  (1990) Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell 63(5):999-1011