PGA3/YML125C Summary

PGA3 BASIC INFORMATION

Standard Name	PGA3 1
Systematic Name	YML125C
Alias	NQR1 2
Feature Type	ORF, Verified
Description	Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking (1, 2, 3)
Name Description	Processing of Gas1p and ALP 1

GO Annotations	All PGA3 GO evidence and references
	View Computational GO annotations for PGA3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chronological cell aging (IMP) protein transport (IMP) replicative cell aging (IMP)
Cellular Component
Manually curated	plasma membrane (IDA)
High-throughput	endoplasmic reticulum (IDA)

Mutant Phenotype	All PGA3 Phenotype details and references
Classical genetics
overexpression	chronological lifespan: increased oxidative phosphorylation: increased replicative lifespan: increased
repressible	Gas1p accumulation: decreased alkaline phosphatase (ALP) modification: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
repressible	cytokinesis: abnormal

Interactions	PGA3 All interactions details and references
	111 total interaction(s) for 58 unique genes/features.
Physical Interactions	Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 54 Phenotypic Suppression: 52 Synthetic Lethality: 2

Sequence Information

ChrXIII:21700 to 20762 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..939	21700..20762	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004594

PGA3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PGA3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PGA3]

1)	Yu L, et al. (2006) A survey of essential gene function in the yeast cell division cycle. Mol Biol Cell 17(11):4736-47
2)	Jimenez-Hidalgo M, et al. (2009) NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8(2):140-51
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91

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