Standard Name	MSS51
Systematic Name	YLR203C
Feature Type	ORF, Verified
Description	Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis (1, 2, 3, 4)
Name Description	Mitochondrial Splicing Suppressor 5

Chromosomal Location	ChrXII:551960 to 550650 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 149 cM

	View Computational GO annotations for MSS51
Molecular Function
Manually curated	translation regulator activity (IMP)
Biological Process
Manually curated	mitochondrial respiratory chain complex IV biogenesis (IMP) positive regulation of mitochondrial translation (IGI, IMP, IPI)
Cellular Component
Manually curated	extrinsic to mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	autophagy: decreased Cox1p accumulation: absent
reduction of function	Cox1p accumulation: decreased respiratory growth: decreased respiratory growth: absent
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased resistance to benzo[a]pyrene: decreased resistance to benzo[a]pyrene: increased resistance to ethanol: decreased resistance to 4-chlorophenol: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased respiratory growth: absent respiratory growth: decreased rate sporulation efficiency: decreased starvation resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	110 total interaction(s) for 54 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-Western: 43 Co-fractionation: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 4 Negative Genetic: 21 Phenotypic Enhancement: 3 Phenotypic Suppression: 6 Positive Genetic: 1 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:551960 to 550650 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 149 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1311 551960..550650 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004193