MET5/YJR137C Summary

MET5 BASIC INFORMATION

Standard Name	MET5 1
Systematic Name	YJR137C
Alias	ECM17 2
Feature Type	ORF, Verified
Description	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine (3, 4)
Name Description	METhionine requiring 1

GO Annotations	All MET5 GO evidence and references
	View Computational GO annotations for MET5
Molecular Function
Manually curated	contributes_to sulfite reductase (NADPH) activity (IDA, TAS)
Biological Process
Manually curated	fungal-type cell wall organization (IMP) sulfate assimilation (IMP)
High-throughput	response to drug (IMP)
Cellular Component
Manually curated	sulfite reductase complex (NADPH) (IDA, TAS)
High-throughput	cytoplasm (IDA)

Pathways	sulfate assimilation pathway superpathway of sulfur amino acid biosynthesis

Mutant Phenotype	All MET5 Phenotype details and references
Classical genetics
null	auxotrophy
reduction of function	auxotrophy hydrogen sulfide excretion: decreased
unspecified	transposable element transposition: decreased
Large-scale survey
null	glycogen accumulation: increased competitive fitness: decreased filamentous growth: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased viable

Interactions	MET5 All interactions details and references
	8 total interaction(s) for 6 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 1
Genetic Interactions	Synthetic Lethality: 1

Sequence Information

ChrX:683275 to 678947 | |

Note: this feature is encoded on the Crick strand.

Genetic position: 84 cM

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4329	683275..678947	2009-02-18	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003898

MET5 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for MET5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MET5]

1)	Masselot M and De Robichon-Szulmajster H (1975) Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet 139(2):121-32
2)	Lussier M, et al. (1997) Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics 147(2):435-50
3)	Hansen J, et al. (1997) Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes. FEBS Lett 401(1):20-4
4)	Mountain HA, et al. (1991) Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast 7(8):781-803

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