VPS53/YJL029C Summary Help

VPS53 BASIC INFORMATION

Standard Name VPS53 1
Systematic Name YJL029C
Feature Type ORF, Verified
Description Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting (1, 2, 3)
Name Description Vacuolar Protein Sorting
GO Annotations All VPS53 GO evidence and references
    View Computational GO annotations for VPS53
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All VPS53 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions VPS53 All interactions details and references
  View additional details at BioGRID
59 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 15
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Reconstituted Complex: 1
Genetic Interactions
  • Negative Genetic: 4
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 8
  • Synthetic Rescue: 2
Sequence Information
ChrX:390847 to 388379 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2009-02-18 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2469 390847..388379 2009-02-18 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003566

VPS53 RESOURCES

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SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for VPS53

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for VPS53]

1) Conibear E and Stevens TH  (2000) Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi. Mol Biol Cell 11(1):305-23
2) Siniossoglou S and Pelham HR  (2001) An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes. EMBO J 20(21):5991-8
3) Siniossoglou S and Pelham HR  (2002) Vps51p links the VFT complex to the SNARE Tlg1p. J Biol Chem 277(50):48318-24