DRN1/YGR093W Summary Help

Standard Name DRN1 1
Systematic Name YGR093W
Feature Type ORF, Verified
Description Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching in vitro; conserved protein with domain organization identical from yeast to human; N-terminal homology to Dbr1p N-terminus, but Dbr1p catalytic residues not conserved; relocalizes to the cytosol in response to hypoxia (1, 2, 3)
Name Description Debranching enzyme-associated RiboNuclease 1
Chromosomal Location
ChrVII:670388 to 671911 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All DRN1 GO evidence and references
  View Computational GO annotations for DRN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
28 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1

Genetic Interactions
  • Negative Genetic: 10
  • Phenotypic Suppression: 1
  • Positive Genetic: 16

Resources
Expression Summary
histogram
Resources
Length (a.a.) 507
Molecular Weight (Da) 58,206
Isoelectric Point (pI) 6.18
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:670388 to 671911 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1524 670388..671911 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003325
References cited on this page View Complete Literature Guide for DRN1
1) Garrey SM, et al.  (2014) A homolog of lariat-debranching enzyme modulates turnover of branched RNA. RNA 20(8):1337-48
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30