CSE1/YGL238W Summary Help

Standard Name CSE1 1
Systematic Name YGL238W
Alias KAP109
Feature Type ORF, Verified
Description Nuclear envelope protein that mediates the nuclear export of Srp1p; Srp1p (importin alpha) is a homolog of metazoan CAS protein; required for accurate chromosome segregation (1, 2, 3)
Name Description Chromosome SEgregation 1
Chromosomal Location
ChrVII:49552 to 52434 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CSE1 GO evidence and references
  View Computational GO annotations for CSE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
conditional
null
overexpression
repressible
Large-scale survey
null
reduction of function
repressible
Resources
68 total interaction(s) for 42 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 5
  • Co-crystal Structure: 1
  • Reconstituted Complex: 7
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 10
  • Positive Genetic: 9
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 960
Molecular Weight (Da) 109,355
Isoelectric Point (pI) 4.95
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:49552 to 52434 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2883 49552..52434 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003207
References cited on this page View Complete Literature Guide for CSE1
1) Xiao Z, et al.  (1993) CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Mol Cell Biol 13(8):4691-702
2) Schroeder AJ, et al.  (1999) Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export receptor, Cse1p. Mol Gen Genet 261(4-5):788-95
3) Hood JK and Silver PA  (1998) Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae. J Biol Chem 273(52):35142-6