CHC1/YGL206C Summary Help

Standard Name CHC1 1
Systematic Name YGL206C
Alias SWA5 2
Feature Type ORF, Verified
Description Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function (1, 3, 4)
Name Description Clathrin Heavy Chain 1
Chromosomal Location
ChrVII:107504 to 102543 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -133 cM
Gene Ontology Annotations All CHC1 GO evidence and references
  View Computational GO annotations for CHC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
overexpression
Resources
162 total interaction(s) for 93 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 48
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 25
  • Co-localization: 7
  • Co-purification: 1
  • PCA: 11
  • Reconstituted Complex: 8
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 10
  • Negative Genetic: 4
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 23
  • Synthetic Lethality: 9
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,653
Molecular Weight (Da) 187,232
Isoelectric Point (pI) 4.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:107504 to 102543 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -133 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4962 107504..102543 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003174
References cited on this page View Complete Literature Guide for CHC1
1) Payne GS and Schekman R  (1985) A test of clathrin function in protein secretion and cell growth. Science 230(4729):1009-14
2) Chen CY and Graham TR  (1998) An arf1Delta synthetic lethal screen identifies a new clathrin heavy chain conditional allele that perturbs vacuolar protein transport in Saccharomyces cerevisiae. Genetics 150(2):577-89
3) Lemmon SK and Jones EW  (1987) Clathrin requirement for normal growth of yeast. Science 238(4826):504-9
4) Gruenberg J and Stenmark H  (2004) The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol 5(4):317-23