ARO1/YDR127W Summary Help

Standard Name ARO1
Systematic Name YDR127W
Feature Type ORF, Verified
Description Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids (1, 2)
Name Description AROmatic amino acid requiring
Chromosomal Location
ChrIV:704484 to 709250 | ORF Map | GBrowse
Gbrowse
Genetic position: 81 cM
Gene Ontology Annotations All ARO1 GO evidence and references
  View Computational GO annotations for ARO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 7 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
476 total interaction(s) for 347 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 61
  • Affinity Capture-RNA: 2
  • Co-purification: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 318
  • Phenotypic Suppression: 2
  • Positive Genetic: 79
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,588
Molecular Weight (Da) 174,754
Isoelectric Point (pI) 6.23
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:704484 to 709250 | ORF Map | GBrowse
SGD ORF map
Genetic position: 81 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4767 704484..709250 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002534
References cited on this page View Complete Literature Guide for ARO1
1) Duncan K, et al.  (1987) The pentafunctional arom enzyme of Saccharomyces cerevisiae is a mosaic of monofunctional domains. Biochem J 246(2):375-86
2) Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press