NPC2/YDL046W Summary Help

Standard Name NPC2 1
Systematic Name YDL046W
Feature Type ORF, Verified
Description Functional homolog of human NPC2/He1; human NPC2 is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes (1)
Name Description Niemann Pick type C homolog 1
Chromosomal Location
ChrIV:371240 to 371761 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NPC2 GO evidence and references
  View Computational GO annotations for NPC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
7 total interaction(s) for 7 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 4

Genetic Interactions
  • Negative Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 173
Molecular Weight (Da) 19,063
Isoelectric Point (pI) 4.18
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:371240 to 371761 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..522 371240..371761 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002204
References cited on this page View Complete Literature Guide for NPC2
1) Berger AC, et al.  (2005) Saccharomyces cerevisiae Npc2p is a functionally conserved homologue of the human Niemann-Pick disease type C 2 protein, hNPC2. Eukaryot Cell 4(11):1851-62