SET1/YHR119W Summary Help

Standard Name SET1 1
Systematic Name YHR119W
Alias YTX1
Feature Type ORF, Verified
Description Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain (2, 3, 4, 5, 6, 7)
Name Description SET domain-containing 1
Gene Product Alias KMT2 8
Chromosomal Location
ChrVIII:346043 to 349285 | ORF Map | GBrowse
Gene Ontology Annotations All SET1 GO evidence and references
  View Computational GO annotations for SET1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 149 genes
Regulators 107 genes
Classical genetics
Large-scale survey
262 total interaction(s) for 131 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 79
  • Affinity Capture-Western: 15
  • Biochemical Activity: 6
  • Co-crystal Structure: 6
  • Co-fractionation: 1
  • Co-localization: 3
  • Co-purification: 16
  • Protein-RNA: 4
  • Reconstituted Complex: 10
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 27
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 9
  • Positive Genetic: 3
  • Synthetic Growth Defect: 19
  • Synthetic Lethality: 8
  • Synthetic Rescue: 38

Expression Summary
Length (a.a.) 1,080
Molecular Weight (Da) 123,911
Isoelectric Point (pI) 9.68
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVIII:346043 to 349285 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..3243 346043..349285 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001161
References cited on this page View Complete Literature Guide for SET1
1) Nislow C, et al.  (1997) SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell 8(12):2421-36
2) Miller T, et al.  (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7
3) Krogan NJ, et al.  (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5
4) Dover J, et al.  (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
5) Boa S, et al.  (2003) Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression. Yeast 20(9):827-35
6) Cheng H, et al.  (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43
7) Terzi N, et al.  (2011) H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol 31(17):3569-83
8) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6