KAP123/YER110C Summary Help

Standard Name KAP123 1
Systematic Name YER110C
Alias YRB4
Feature Type ORF, Verified
Description Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 (2, 3, 4)
Name Description KAryoPherin 1
Chromosomal Location
ChrV:382103 to 378762 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All KAP123 GO evidence and references
  View Computational GO annotations for KAP123
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
overexpression
repressible
Large-scale survey
null
overexpression
Resources
268 total interaction(s) for 180 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 147
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 19
  • Co-fractionation: 1
  • Co-localization: 1
  • Co-purification: 3
  • Protein-peptide: 2
  • Reconstituted Complex: 25
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 39
  • Phenotypic Enhancement: 1
  • Positive Genetic: 12
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,113
Molecular Weight (Da) 122,600
Isoelectric Point (pI) 4.36
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:382103 to 378762 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3342 382103..378762 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000912
References cited on this page View Complete Literature Guide for KAP123
1) Rout MP, et al.  (1997) A distinct nuclear import pathway used by ribosomal proteins. Cell 89(5):715-25
2) Schlenstedt G, et al.  (1997) Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J 16(20):6237-49
3) Sydorskyy Y, et al.  (2003) Intersection of the Kap123p-mediated nuclear import and ribosome export pathways. Mol Cell Biol 23(6):2042-54
4) Mosammaparast N, et al.  (2002) Pathways mediating the nuclear import of histones H3 and H4 in yeast. J Biol Chem 277(1):862-8