CIN8/YEL061C Summary Help

Standard Name CIN8 1
Systematic Name YEL061C
Alias KSL2 , SDS15 2
Feature Type ORF, Verified
Description Kinesin motor protein; involved in mitotic spindle assembly and chromosome segregation (1, 3, 4)
Name Description Chromosome INstability 5
Chromosomal Location
ChrV:39537 to 36535 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CIN8 GO evidence and references
  View Computational GO annotations for CIN8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
518 total interaction(s) for 251 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-Western: 3
  • Biochemical Activity: 2
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 12

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Negative Genetic: 175
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 10
  • Positive Genetic: 6
  • Synthetic Growth Defect: 68
  • Synthetic Lethality: 203
  • Synthetic Rescue: 11

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,000
Molecular Weight (Da) 113,310
Isoelectric Point (pI) 8.17
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:39537 to 36535 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2003-09-22 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3003 39537..36535 2003-09-22 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000787
References cited on this page View Complete Literature Guide for CIN8
1) Hoyt MA, et al.  (1992) Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J Cell Biol 118(1):109-20
2) Sussel L, et al.  (1995) Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics 141(3):873-88
3) Saunders WS and Hoyt MA  (1992) Kinesin-related proteins required for structural integrity of the mitotic spindle. Cell 70(3):451-8
4) Roof DM, et al.  (1992) Kinesin-related proteins required for assembly of the mitotic spindle. J Cell Biol 118(1):95-108
5) Stearns T, et al.  (1990) Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124(2):251-62