CSM1/YCR086W Summary

CSM1/YCR086W Summary

Standard Name	CSM1 1
Systematic Name	YCR086W
Feature Type	ORF, Verified
Description	Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation (2, 3, 4)
Name Description	Chromosome Segregation in Meiosis 1

Chromosomal Location	ChrIII:263392 to 263964 \| ORF Map \| GBrowse

Gene Ontology Annotations All CSM1 GO evidence and references

	View Computational GO annotations for CSM1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	homologous chromosome segregation (IMP, IPI) meiotic chromosome segregation (IMP) protein localization to nucleolar rDNA repeats (IMP) rDNA condensation (IMP)
Cellular Component
Manually curated	monopolin complex (IDA) nuclear envelope (IDA) nucleolus (IDA)

Mutant phenotypes All CSM1 Phenotype evidence and references

Classical genetics
null	chromosome/plasmid maintenance: abnormal cold sensitivity: increased colony sectoring: increased Ptr2p-GFP accumulation: increased resistance to benomyl: decreased resistance to manganese(2+): decreased
unspecified	chromosome segregation: abnormal sporulation: abnormal
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased meiosis: abnormal nutrient utilization: increased resistance to bleomycin: increased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to amiodarone: decreased resistance to CTBT: decreased resistance to fenpropimorph: decreased resistance to dimethyl sulfoxide: decreased resistance to dihydromotuporamine C: decreased spore germination: decreased sporulation: decreased stress resistance: decreased telomere length: increased toxin resistance: decreased vegetative growth: decreased rate vegetative growth: abnormal viable
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All CSM1 Interaction evidence and references

	469 total interaction(s) for 281 unique genes/features.
Physical Interactions	Affinity Capture-MS: 32 Affinity Capture-Western: 12 Co-crystal Structure: 3 Co-localization: 4 Reconstituted Complex: 7 Two-hybrid: 61
Genetic Interactions	Negative Genetic: 192 Phenotypic Enhancement: 3 Phenotypic Suppression: 7 Positive Genetic: 25 Synthetic Growth Defect: 86 Synthetic Lethality: 35 Synthetic Rescue: 2
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder \| YeastRC Two-Hybrid

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All CSM1 Protein evidence and references

Localization	YeastRC \| Organelle DB (UMich) \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP
Homologs	Ashbya (AGD) \| CGD Homologs \| CandidaDB Homologs \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrIII:263392 to 263964 | |

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..573	263392..263964	2011-02-03	1997-01-28

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000000682

References cited on this page View Complete Literature Guide for CSM1

1)	Rabitsch KP, et al. (2001) A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr Biol 11(13):1001-9
2)	Rabitsch KP, et al. (2003) Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell 4(4):535-48
3)	Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
4)	Johzuka K and Horiuchi T (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35