BIK1/YCL029C Summary Help

Standard Name BIK1 1
Systematic Name YCL029C
Alias ARM5 , PAC14 2
Feature Type ORF, Verified
Description Microtubule-associated protein; component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 (3)
Name Description BIlateral Karyogamy defect 1
Chromosomal Location
ChrIII:69921 to 68599 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -21 cM
Gene Ontology Annotations All BIK1 GO evidence and references
  View Computational GO annotations for BIK1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
conditional
null
overexpression
reduction of function
Large-scale survey
null
overexpression
Resources
276 total interaction(s) for 151 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-Western: 11
  • Biochemical Activity: 4
  • Co-fractionation: 1
  • Co-localization: 2
  • Co-purification: 1
  • PCA: 4
  • Reconstituted Complex: 4
  • Two-hybrid: 60

Genetic Interactions
  • Dosage Growth Defect: 2
  • Negative Genetic: 89
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 7
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 57
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 440
Molecular Weight (Da) 51,092
Isoelectric Point (pI) 5.81
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:69921 to 68599 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -21 cM
Last Update Coordinates: 2000-09-13 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1323 69921..68599 2000-09-13 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000534
References cited on this page View Complete Literature Guide for BIK1
1) Trueheart J, et al.  (1987) Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol Cell Biol 7(7):2316-28
2) Geiser JR, et al.  (1997) Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways. Mol Biol Cell 8(6):1035-50
3) Berlin V, et al.  (1990) BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin. J Cell Biol 111(6 Pt 1):2573-86