DCC1/YCL016C Summary

DCC1/YCL016C Summary

Standard Name	DCC1
Systematic Name	YCL016C
Feature Type	ORF, Verified
Description	Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance (1, 2)
Name Description	Defective in sister Chromatid Cohesion

Chromosomal Location	ChrIII:95763 to 94621 \| ORF Map \| GBrowse
	Note: this feature is encoded on the Crick strand.

Gene Ontology Annotations All DCC1 GO evidence and references

	View Computational GO annotations for DCC1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	maintenance of DNA trinucleotide repeats (IMP) mitotic sister chromatid cohesion (IGI, IMP)
High-throughput	response to DNA damage stimulus (IMP)
Cellular Component
Manually curated	Ctf18 RFC-like complex (IPI)

Mutant phenotypes All DCC1 Phenotype evidence and references

Classical genetics
null	X ray resistance: increased chromosome segregation: abnormal chromosome/plasmid maintenance: abnormal colony sectoring: increased resistance to hydroxyurea: decreased resistance to camptothecin: decreased resistance to benomyl: decreased resistance to bortezomib: decreased
Large-scale survey
null	budding index: increased cell size: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate haploproficient heat sensitivity: increased resistance to hydroxyurea: decreased resistance to sirolimus: decreased resistance to benomyl: decreased resistance to camptothecin: decreased resistance to methyl methanesulfonate: decreased resistance to tunicamycin: increased resistance to mycophenolic acid: increased resistance to fluconazole: increased resistance to sodium selenide: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to sodium arsenite: decreased resistance to doxorubicin: decreased resistance to sorbate: decreased resistance to benzo[a]pyrene: decreased resistance to cisplatin: decreased sporulation efficiency: increased telomere length: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: abnormal viable
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All DCC1 Interaction evidence and references

	624 total interaction(s) for 313 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-Western: 1 PCA: 1 Reconstituted Complex: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Negative Genetic: 263 Phenotypic Enhancement: 5 Phenotypic Suppression: 3 Positive Genetic: 32 Synthetic Growth Defect: 228 Synthetic Lethality: 80 Synthetic Rescue: 2
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All DCC1 Protein evidence and references

Localization	YeastRC \| Organelle DB (UMich) \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| CGD Homologs \| CandidaDB Homologs \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrIII:95763 to 94621 | |

Note: this feature is encoded on the Crick strand.

SGD ORF map

Last Update

Coordinates: 2006-01-12 | Sequence: 2000-09-13

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1143	95763..94621	2006-01-12	2000-09-13

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000000521

References cited on this page View Complete Literature Guide for DCC1

1)	Mayer ML, et al. (2001) Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell 7(5):959-70
2)	Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63