ROM2/YLR371W Summary Help

Standard Name ROM2 1
Systematic Name YLR371W
Feature Type ORF, Verified
Description GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication (1, 2, 3)
Name Description RhO1 Multicopy suppressor 1
Chromosomal Location
ChrXII:862714 to 866784 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ROM2 GO evidence and references
  View Computational GO annotations for ROM2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
unspecified
Resources
360 total interaction(s) for 257 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Biochemical Activity: 3
  • Co-localization: 1
  • PCA: 3
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Rescue: 31
  • Negative Genetic: 142
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 10
  • Positive Genetic: 13
  • Synthetic Growth Defect: 25
  • Synthetic Lethality: 71
  • Synthetic Rescue: 19

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,356
Molecular Weight (Da) 152,595
Isoelectric Point (pI) 9.97
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:862714 to 866784 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4071 862714..866784 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004363
References cited on this page View Complete Literature Guide for ROM2
1) Ozaki K, et al.  (1996) Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J 15(9):2196-207
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Krause SA, et al.  (2012) Functional specialisation of yeast Rho1 GTP exchange factors. J Cell Sci 125(Pt 11):2721-31