Standard Name	RTT103 1
Systematic Name	YDR289C
Feature Type	ORF, Verified
Description	Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition (1, 2)
Name Description	Regulator of Ty1 Transposition 1

Chromosomal Location	ChrIV:1039509 to 1038280 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RTT103
Molecular Function
Manually curated	RNA polymerase II core binding (IDA, IPI)
Biological Process
Manually curated	mRNA 3'-end processing (IGI, IMP) negative regulation of transposition, RNA-mediated (IMP)
Cellular Component
Manually curated	nuclear chromatin (IDA) site of double-strand break (IDA)

Classical genetics
null	UV resistance: decreased cold sensitivity: increased metal resistance: decreased resistance to methyl methanesulfonate: decreased resistance to tellurite: increased sporulation: decreased
Large-scale survey
null	auxotrophy glycogen accumulation: increased colony sectoring: increased competitive fitness: decreased dessication resistance: decreased haploproficient metal resistance: increased Rad52-YFP distribution: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to bleomycin: increased resistance to sirolimus: increased resistance to tunicamycin: increased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to quinine: decreased resistance to methyl methanesulfonate: decreased resistance to cycloheximide: decreased resistance to fenpropimorph: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to dimethyl sulfoxide: decreased resistance to camptothecin: decreased stress resistance: decreased transposable element transposition: increased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	407 total interaction(s) for 303 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-RNA: 2 Co-crystal Structure: 1 PCA: 2 Protein-peptide: 4 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 275 Phenotypic Enhancement: 5 Phenotypic Suppression: 2 Positive Genetic: 44 Synthetic Growth Defect: 35 Synthetic Lethality: 13 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1039509 to 1038280 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1230 1039509..1038280 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002697