RTS1/YOR014W Summary Help

Standard Name RTS1 1
Systematic Name YOR014W
Alias SCS1 2
Feature Type ORF, Verified
Description B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A (1, 3, 4, 5)
Name Description Rox Three Suppressor 1
Chromosomal Location
ChrXV:357674 to 359947 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RTS1 GO evidence and references
  View Computational GO annotations for RTS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
323 total interaction(s) for 209 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 33
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 7
  • Biochemical Activity: 1
  • PCA: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Negative Genetic: 157
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 6
  • Positive Genetic: 49
  • Synthetic Growth Defect: 20
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 13
  • Synthetic Rescue: 17

Resources
Expression Summary
histogram
Resources
Length (a.a.) 757
Molecular Weight (Da) 85,334
Isoelectric Point (pI) 6.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:357674 to 359947 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2274 357674..359947 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005540
References cited on this page View Complete Literature Guide for RTS1
1) Shu Y, et al.  (1997) Molecular genetic analysis of Rts1p, a B' regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2A. Mol Cell Biol 17(6):3242-53
2) Shu Y and Hallberg RL  (1995) SCS1, a multicopy suppressor of hsp60-ts mutant alleles, does not encode a mitochondrially targeted protein. Mol Cell Biol 15(10):5618-26
3) Zhao Y, et al.  (1997) Saccharomyces cerevisiae homologs of mammalian B and B' subunits of protein phosphatase 2A direct the enzyme to distinct cellular functions. J Biol Chem 272(13):8256-62
4) Dobbelaere J, et al.  (2003) Phosphorylation-dependent regulation of septin dynamics during the cell cycle. Dev Cell 4(3):345-57
5) Bizzari F and Marston AL  (2011) Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis. J Cell Biol 193(7):1213-28