Standard Name	RTG3 1
Systematic Name	YBL103C
Feature Type	ORF, Verified
Description	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways (2, 3)
Name Description	ReTroGrade regulation 1

Chromosomal Location	ChrII:23536 to 22076 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RTG3
Molecular Function
Manually curated	RNA polymerase II transcription factor binding (IPI) sequence-specific DNA binding RNA polymerase II transcription factor activity (IDA, IMP)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	cellular response to oleic acid (IMP) mitochondria-nucleus signaling pathway (IDA) mitochondrion degradation (IMP) positive regulation of transcription from RNA polymerase II promoter (IDA, IMP) transcription factor import into nucleus (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Binding motifs	Predicted RTG3 Binding Site Locations
	GGTCAC 1 [Search intergenic regions for GGTCAC] KCACGTGM 4 [Search intergenic regions for KCACGTGM]
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	auxotrophy resistance to pterostilbene: increased resistance to sirolimus: increased resistance to hydroxyurea: decreased utilization of carbon source: decreased
Large-scale survey
null	competitive fitness: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased resistance to ethanol: decreased resistance to hydroxyurea: decreased resistance to wortmannin: decreased resistance to mycophenolic acid: increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to hydrogen chloride: increased resistance to sirolimus: increased resistance to cycloheximide: decreased resistance to camptothecin: decreased resistance to caffeine: decreased resistance to sodium selenide: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	339 total interaction(s) for 274 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 2 Co-localization: 1 Reconstituted Complex: 2 Two-hybrid: 20
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 216 Phenotypic Enhancement: 1 Positive Genetic: 58 Synthetic Growth Defect: 7 Synthetic Lethality: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:23536 to 22076 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-07-27
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1461 23536..22076 2011-02-03 1997-07-27
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000199