RTG3/YBL103C Summary Help

Standard Name RTG3 1
Systematic Name YBL103C
Feature Type ORF, Verified
Description bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways; forms a complex with another bHLH/Zip protein, Rtg1p, to activate the pathways; target of Hog1p (2, 3, 4)
Name Description ReTroGrade regulation 1
Chromosomal Location
ChrII:23536 to 22076 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RTG3 GO evidence and references
  View Computational GO annotations for RTG3
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 73 genes
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
343 total interaction(s) for 278 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 3
  • Biochemical Activity: 2
  • Co-localization: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 20

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 217
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 58
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 486
Molecular Weight (Da) 54,139
Isoelectric Point (pI) 5.73
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:23536 to 22076 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-07-27
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1461 23536..22076 2011-02-03 1997-07-27
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000199
References cited on this page View Complete Literature Guide for RTG3
1) Jia Y, et al.  (1997) A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol Cell Biol 17(3):1110-7
2) Rothermel BA, et al.  (1997) Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains. J Biol Chem 272(32):19801-7
3) Crespo JL, et al.  (2002) The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci U S A 99(10):6784-9
4) Ruiz-Roig C, et al.  (2012) The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms. Mol Biol Cell 23(21):4286-96
5) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66