RTC6/YPL183W-A Summary Help

Standard Name RTC6 1
Systematic Name YPL183W-A
Alias TAE4 2
Feature Type ORF, Verified
Description Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description Restriction of Telomere Capping 1
Chromosomal Location
ChrXVI:199095 to 199376 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RTC6 GO evidence and references
  View Computational GO annotations for RTC6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
133 total interaction(s) for 107 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Rescue: 18
  • Negative Genetic: 76
  • Positive Genetic: 3
  • Synthetic Growth Defect: 28
  • Synthetic Lethality: 1
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 93
Molecular Weight (Da) 10,698
Isoelectric Point (pI) 11.89
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:199095 to 199376 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..282 199095..199376 2011-02-03 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Retired NameGON5
Primary SGDIDS000007224
References cited on this page View Complete Literature Guide for RTC6
1) Addinall SG, et al.  (2008) A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae. Genetics 180(4):2251-66
2) Alamgir M, et al.  (2010) Chemical-genetic profile analysis of five inhibitory compounds in yeast. BMC Chem Biol 10():6
3) Andrade MA, et al.  (1997) Characterization of new proteins found by analysis of short open reading frames from the full yeast genome. Yeast 13(14):1363-74
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76