Standard Name	RSC8 1
Systematic Name	YFR037C
Alias	SWH3 2
Feature Type	ORF, Verified
Description	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters (1, 2, 3, 4)
Name Description	Remodel the Structure of Chromatin 1

Chromosomal Location	ChrVI:229186 to 227513 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RSC8
Molecular Function
Manually curated	DNA binding (IDA) contributes_to DNA translocase activity (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) double-strand break repair via nonhomologous end joining (IDA, IMP) G1/S transition of mitotic cell cycle (IMP) nucleosome disassembly (IDA) regulation of transcription, DNA-dependent (IMP) transcription elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
repressible	cell cycle progression in G1 phase: arrested cell cycle progression through the G2/M phase transition: arrested
Large-scale survey
conditional	colony sectoring: increased
null	haploproficient inviable
reduction of function	competitive fitness: increased telomere length: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	291 total interaction(s) for 156 unique genes/features.
Physical Interactions	Affinity Capture-MS: 160 Affinity Capture-RNA: 5 Affinity Capture-Western: 9 Biochemical Activity: 2 Co-fractionation: 1 Co-localization: 4 Co-purification: 1 Reconstituted Complex: 7 Two-hybrid: 11
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 5 Negative Genetic: 55 Phenotypic Enhancement: 2 Positive Genetic: 18 Synthetic Growth Defect: 3 Synthetic Lethality: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVI:229186 to 227513 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1674 229186..227513 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001933