RSC8/YFR037C Summary Help

Standard Name RSC8 1
Systematic Name YFR037C
Alias SWH3 2
Feature Type ORF, Verified
Description Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters (1, 2, 3, 4)
Name Description Remodel the Structure of Chromatin 1
Chromosomal Location
ChrVI:229186 to 227513 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RSC8 GO evidence and references
  View Computational GO annotations for RSC8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 2361 genes
Regulators 109 genes
Resources
Classical genetics
repressible
Large-scale survey
conditional
null
reduction of function
Resources
296 total interaction(s) for 158 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 165
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 9
  • Biochemical Activity: 2
  • Co-fractionation: 1
  • Co-localization: 4
  • Co-purification: 1
  • Reconstituted Complex: 7
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 5
  • Negative Genetic: 55
  • Phenotypic Enhancement: 2
  • Positive Genetic: 18
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 557
Molecular Weight (Da) 63,168
Isoelectric Point (pI) 5.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVI:229186 to 227513 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1674 229186..227513 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001933
References cited on this page View Complete Literature Guide for RSC8
1) Cairns BR, et al.  (1996) RSC, an essential, abundant chromatin-remodeling complex. Cell 87(7):1249-60
2) Treich I and Carlson M  (1997) Interaction of a Swi3 homolog with Sth1 provides evidence for a Swi/Snf-related complex with an essential function in Saccharomyces cerevisiae. Mol Cell Biol 17(4):1768-75
3) Lorch Y, et al.  (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34
4) Neely KE and Workman JL  (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29