RSC58/YLR033W Summary Help

Standard Name RSC58 1
Systematic Name YLR033W
Feature Type ORF, Verified
Description Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance (1, 2)
Name Description Remodel the Structure of Chromatin 1
Chromosomal Location
ChrXII:208761 to 210269 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RSC58 GO evidence and references
  View Computational GO annotations for RSC58
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 97 genes
Resources
Classical genetics
repressible
Large-scale survey
conditional
null
reduction of function
repressible
Resources
167 total interaction(s) for 71 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 122
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • PCA: 5
  • Reconstituted Complex: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 26
  • Positive Genetic: 4
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 502
Molecular Weight (Da) 57,794
Isoelectric Point (pI) 8.31
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:208761 to 210269 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1509 208761..210269 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004023
References cited on this page View Complete Literature Guide for RSC58
1) Sanders SL, et al.  (2002) Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry. Mol Cell Biol 22(13):4723-38
2) Carey M, et al.  (2006) RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation. Mol Cell 24(3):481-7