Standard Name	RSC4
Systematic Name	YKR008W
Feature Type	ORF, Verified
Description	Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p (1, 2, 3, 4, 5, 6)
Name Description	Remodel the Structure of Chromatin 7

Chromosomal Location	ChrXI:452201 to 454078 | ORF Map | GBrowse

	View Computational GO annotations for RSC4
Molecular Function
Manually curated	contributes_to DNA translocase activity (IDA) histone acetyl-lysine binding (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) G2/M transition of mitotic cell cycle (IMP) nucleosome disassembly (IDA) transcription elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)

Classical genetics
conditional	heat sensitivity: increased
null	inviable
repressible	cell cycle progression through the G2/M phase transition: arrested
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal
null	haploinsufficient inviable
overexpression	resistance to sirolimus: increased
reduction of function	competitive fitness: increased telomere length: increased
repressible	mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	238 total interaction(s) for 136 unique genes/features.
Physical Interactions	Affinity Capture-MS: 106 Affinity Capture-Western: 10 Biochemical Activity: 1 Co-crystal Structure: 3 Co-purification: 3 PCA: 1 Protein-peptide: 1 Reconstituted Complex: 5 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 64 Phenotypic Enhancement: 1 Positive Genetic: 18 Synthetic Growth Defect: 1 Synthetic Lethality: 15 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:452201 to 454078 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1878 452201..454078 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001716