RSC1/YGR056W Summary Help

Standard Name RSC1 1
Systematic Name YGR056W
Feature Type ORF, Verified
Description Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description Remodel the Structure of Chromatin 6
Chromosomal Location
ChrVII:601661 to 604447 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RSC1 GO evidence and references
  View Computational GO annotations for RSC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
273 total interaction(s) for 175 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 69
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 10
  • Co-purification: 10
  • Reconstituted Complex: 5
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 85
  • Phenotypic Suppression: 3
  • Positive Genetic: 26
  • Synthetic Growth Defect: 38
  • Synthetic Lethality: 14
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 928
Molecular Weight (Da) 106,668
Isoelectric Point (pI) 6.49
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:601661 to 604447 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2787 601661..604447 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003288
References cited on this page View Complete Literature Guide for RSC1
1) Cairns BR, et al.  (1999) Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol Cell 4(5):715-23
2) Lorch Y, et al.  (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34
3) Neely KE and Workman JL  (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29
4) Bungard D, et al.  (2004) RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae. Eukaryot Cell 3(4):910-8
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Cairns BR, et al.  (1996) RSC, an essential, abundant chromatin-remodeling complex. Cell 87(7):1249-60