RSC1/YGR056W Summary Help

Standard Name RSC1 1
Systematic Name YGR056W
Feature Type ORF, Verified
Description Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description Remodel the Structure of Chromatin 6
Chromosomal Location
ChrVII:601661 to 604447 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RSC1 GO evidence and references
  View Computational GO annotations for RSC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 1164 genes
Regulators 80 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
273 total interaction(s) for 175 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 69
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 10
  • Co-purification: 10
  • Reconstituted Complex: 5
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 85
  • Phenotypic Suppression: 3
  • Positive Genetic: 26
  • Synthetic Growth Defect: 38
  • Synthetic Lethality: 14
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 928
Molecular Weight (Da) 106,668
Isoelectric Point (pI) 6.49
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:601661 to 604447 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2787 601661..604447 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003288
References cited on this page View Complete Literature Guide for RSC1
1) Cairns BR, et al.  (1999) Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol Cell 4(5):715-23
2) Lorch Y, et al.  (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34
3) Neely KE and Workman JL  (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29
4) Bungard D, et al.  (2004) RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae. Eukaryot Cell 3(4):910-8
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Cairns BR, et al.  (1996) RSC, an essential, abundant chromatin-remodeling complex. Cell 87(7):1249-60