Standard Name	RRT2 1
Systematic Name	YBR246W
Alias	ERE1 2 , DPH7 3 , 4
Feature Type	ORF, Verified
Description	Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription (1, 2, 4, 5, 6)
Name Description	Regulator of rDNA Transcription 1

Chromosomal Location	ChrII:711591 to 712754 | ORF Map | GBrowse

	View Computational GO annotations for RRT2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	endocytic recycling (IMP) peptidyl-diphthamide biosynthetic process from peptidyl-histidine (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) endosome (IDA)

Pathways	diphthamide biosynthesis

Classical genetics
null	tellurium atom accumulation: increased
Large-scale survey
null	competitive fitness: decreased haploproficient resistance to hygromycin B: decreased resistance to L-canavanine: increased resistance to sodium selenide: decreased resistance to benzo[a]pyrene: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	28 total interaction(s) for 27 unique genes/features.
Physical Interactions	Affinity Capture-Western: 2 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 15 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 1 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:711591 to 712754 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1164 711591..712754 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000450