Standard Name	RRT12 1
Systematic Name	YCR045C
Alias	OSW3 2 , 3
Feature Type	ORF, Verified
Description	Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores (1, 3, 4)
Name Description	Regulator of rDNA Transcription 1

Chromosomal Location	ChrIII:209610 to 208135 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RRT12
Molecular Function
Manually curated	serine-type peptidase activity (ISS)
Biological Process
Manually curated	ascospore wall assembly (IMP)
Cellular Component
Manually curated	ascospore wall (IDA) nuclear envelope (IDA)

Classical genetics
null	colony appearance: abnormal Spr1-GFP distribution: abnormal resistance to tellurite: decreased spore wall formation: abnormal
Large-scale survey
null	acid pH resistance: decreased auxotrophy cell size: increased glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased hyperosmotic stress resistance: decreased resistance to ethanol: decreased resistance to arsenite(3-): decreased resistance to sodium selenide: decreased resistance to cycloheximide: decreased sporulation: normal sporulation efficiency: decreased stress resistance: decreased toxin resistance: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	4 total interaction(s) for 4 unique genes/features.
Physical Interactions	Two-hybrid: 1
Genetic Interactions	Positive Genetic: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:209610 to 208135 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	This feature contains embedded feature(s): YCR045W-A
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1476 209610..208135 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000641