RRN6/YBL014C Summary

RRN6 BASIC INFORMATION

Standard Name	RRN6 1
Systematic Name	YBL014C
Feature Type	ORF, Verified
Description	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p (2, 3, 4)
Name Description	Regulation of RNA polymerase I 1

GO Annotations	All RRN6 GO evidence and references
	View Computational GO annotations for RRN6
Molecular Function
Manually curated	promoter binding (NAS) RNA polymerase I transcription factor activity (IDA, IMP)
Biological Process
Manually curated	transcription from RNA polymerase I promoter (IDA, IMP) transcription initiation from RNA polymerase I promoter (NAS) transcription of nuclear rRNA large RNA polymerase I transcript (IGI)
Cellular Component
Manually curated	RNA polymerase I core factor complex (IDA)

Mutant Phenotype	All RRN6 Phenotype details and references
Classical genetics
conditional	rRNA species transcribed by RNA polymerase I accumulation: decreased heat sensitivity: increased
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased
repressible	cell cycle progression in G1 phase: abnormal

Interactions	RRN6 All interactions details and references
	29 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Biochemical Activity: 4 Co-purification: 1 Protein-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 9
Genetic Interactions	Synthetic Rescue: 2

Sequence Information

ChrII:201751 to 199067 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2685	201751..199067	2004-07-16	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000110

RRN6 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RRN6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RRN6]

1)	Nogi Y, et al. (1991) An approach for isolation of mutants defective in 35S ribosomal RNA synthesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(16):7026-30
2)	Lin CW, et al. (1996) A novel 66-kilodalton protein complexes with Rrn6, Rrn7, and TATA-binding protein to promote polymerase I transcription initiation in Saccharomyces cerevisiae. Mol Cell Biol 16(11):6436-43
3)	Keys DA, et al. (1994) RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae. Genes Dev 8(19):2349-62
4)	Lalo D, et al. (1996) RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I. J Biol Chem 271(35):21062-7

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