RRI2/YOL117W Summary Help

Standard Name RRI2 1
Systematic Name YOL117W
Alias CSN10
Feature Type ORF, Verified
Description Subunit of the COP9 signalosome (CSN) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response (1, 2)
Chromosomal Location
ChrXV:97551 to 99488 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RRI2 GO evidence and references
  View Computational GO annotations for RRI2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
62 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 44
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 7
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 645
Molecular Weight (Da) 76,388
Isoelectric Point (pI) 4.68
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:97551 to 99488 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1938 97551..99488 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005477
References cited on this page View Complete Literature Guide for RRI2
1) Wee S, et al.  (2002) Conservation of the COP9/signalosome in budding yeast. BMC Genet 3():15
2) Maytal-Kivity V, et al.  (2002) COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep 3(12):1215-21