Standard Name	RRD2 1
Systematic Name	YPL152W
Alias	YPA2
Feature Type	ORF, Verified
Description	Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6, 7, 8)
Name Description	Resistant to Rapamycin Deletion 1

Chromosomal Location	ChrXVI:265028 to 266104 | ORF Map | GBrowse

	View Computational GO annotations for RRD2
Molecular Function
Manually curated	peptidyl-prolyl cis-trans isomerase activity (IDA) protein phosphatase type 2A regulator activity (IGI, IMP, ISS)
Biological Process
Manually curated	mitotic spindle organization in nucleus (IMP) response to osmotic stress (IGI, IMP)
Cellular Component
Manually curated	protein phosphatase type 2A complex (IDA)

Regulatory modules	predicted: cellcycle (353)

Classical genetics
null	resistance to sirolimus: increased resistance to caffeine: increased
Large-scale survey
null	competitive fitness: decreased heat sensitivity: increased resistance to neothyonidioside: decreased resistance to nickel sulfate: decreased resistance to wortmannin: normal resistance to L-canavanine: increased resistance to sirolimus: increased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	88 total interaction(s) for 62 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 2 Affinity Capture-Western: 10 Reconstituted Complex: 2 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 37 Phenotypic Enhancement: 1 Positive Genetic: 10 Synthetic Growth Defect: 5 Synthetic Lethality: 8 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:265028 to 266104 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1077 265028..266104 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006073