RRD2/YPL152W Summary Help

RRD2 BASIC INFORMATION

Standard Name RRD2 1
Systematic Name YPL152W
Alias YPA2
Feature Type ORF, Verified
Description Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex (1, 2, 3, 4, 5, 6, 7)
Name Description Resistant to Rapamycin Deletion 1
GO Annotations All RRD2 GO evidence and references
    View Computational GO annotations for RRD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: cellcycle ( 353 )
Mutant Phenotype All RRD2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions RRD2 All interactions details and references
63 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 10
  • Reconstituted Complex: 2
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 22
  • Phenotypic Suppression: 8
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 7
  • Synthetic Rescue: 2
Sequence Information
ChrXVI:265027 to 266103 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1077 265027..266103 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000006073

RRD2 RESOURCES

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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for RRD2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RRD2]

1) Rempola B, et al.  (2000) Functional analysis of RRD1 (YIL153w) and RRD2 (YPL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae. Mol Gen Genet 262(6):1081-92
2) Mitchell DA and Sprague GF Jr  (2001) The phosphotyrosyl phosphatase activator, Ncs1p (Rrd1p), functions with Cla4p to regulate the G(2)/M transition in Saccharomyces cerevisiae. Mol Cell Biol 21(2):488-500
3) Van Hoof C, et al.  (2001) The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations. Exp Cell Res 264(2):372-87
4) Van Hoof C, et al.  (1998) Functional analysis of conserved domains in the phosphotyrosyl phosphatase activator. Molecular cloning of the homologues from Drosophila melanogaster and Saccharomyces cerevisiae. Biochemistry 37(37):12899-908
5) Zheng Y and Jiang Y  (2005) The yeast phosphotyrosyl phosphatase activator is part of the Tap42-phosphatase complexes. Mol Biol Cell 16(4):2119-27
6) Fellner T, et al.  (2003) A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. Genes Dev 17(17):2138-50
7) Jordens J, et al.  (2006) The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase. J Biol Chem 281(10):6349-57