Standard Name	RPT5 1
Systematic Name	YOR117W
Alias	YTA1 2
Feature Type	ORF, Verified
Description	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 (2, 3, 4, 5, 6)
Name Description	Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 1

Chromosomal Location	ChrXV:545029 to 546333 | ORF Map | GBrowse

	View Computational GO annotations for RPT5
Molecular Function
Manually curated	ATPase activity (ISS)
Biological Process
Manually curated	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly (IMP) proteasome regulatory particle assembly (IMP) ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	proteasome regulatory particle, base subcomplex (IDA)

Classical genetics
null	inviable
overexpression	viability: decreased
reduction of function	budding index: increased heat sensitivity: increased replicative lifespan: decreased resistance to canavanine: decreased vegetative growth: decreased
Large-scale survey
null	cell size: increased haploinsufficient inviable resistance to clioquinol: decreased
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased telomere length: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	542 total interaction(s) for 362 unique genes/features.
Physical Interactions	Affinity Capture-MS: 320 Affinity Capture-RNA: 2 Affinity Capture-Western: 46 Biochemical Activity: 4 Co-fractionation: 3 Co-purification: 8 PCA: 16 Reconstituted Complex: 7 Two-hybrid: 95
Genetic Interactions	Negative Genetic: 2 Phenotypic Suppression: 1 Positive Genetic: 34 Synthetic Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:545029 to 546333 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1305 545029..546333 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005643