RPT5/YOR117W Summary Help

Standard Name RPT5 1
Systematic Name YOR117W
Alias YTA1 2
Feature Type ORF, Verified
Description ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 (2, 3, 4, 5, 6)
Name Description Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 1
Chromosomal Location
ChrXV:545029 to 546333 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RPT5 GO evidence and references
  View Computational GO annotations for RPT5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
overexpression
reduction of function
Large-scale survey
null
reduction of function
unspecified
Resources
560 total interaction(s) for 369 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 326
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 46
  • Biochemical Activity: 4
  • Co-fractionation: 3
  • Co-purification: 8
  • PCA: 16
  • Reconstituted Complex: 7
  • Two-hybrid: 95

Genetic Interactions
  • Negative Genetic: 9
  • Phenotypic Suppression: 1
  • Positive Genetic: 38
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 434
Molecular Weight (Da) 48,255
Isoelectric Point (pI) 4.76
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:545029 to 546333 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1305 545029..546333 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005643
References cited on this page View Complete Literature Guide for RPT5
1) Finley D, et al.  (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2) Schnall R, et al.  (1994) Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10(9):1141-55
3) Glickman MH, et al.  (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol 18(6):3149-62
4) Glickman MH, et al.  (1999) Functional analysis of the proteasome regulatory particle. Mol Biol Rep 26(1-2):21-8
5) Rubin DM, et al.  (1998) Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. EMBO J 17(17):4909-19
6) Gonzalez F, et al.  (2002) Recruitment of a 19S proteasome subcomplex to an activated promoter. Science 296(5567):548-50