RPT3/YDR394W Summary

RPT3 BASIC INFORMATION

Standard Name	RPT3 1
Systematic Name	YDR394W
Alias	YNT1 , YTA2 2
Feature Type	ORF, Verified
Description	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B (3, 4, 5, 6)
Name Description	Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 1

GO Annotations	All RPT3 GO evidence and references
	View Computational GO annotations for RPT3
Molecular Function
Manually curated	ATPase activity (IDA, TAS) endopeptidase activity (TAS)
Biological Process
Manually curated	ubiquitin-dependent protein catabolic process (TAS)
Cellular Component
Manually curated	proteasome regulatory particle, base subcomplex (IDA, IPI)

Mutant Phenotype	All RPT3 Phenotype details and references
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased

Interactions	RPT3 All interactions details and references
	210 total interaction(s) for 82 unique genes/features.
Physical Interactions	Affinity Capture-MS: 125 Affinity Capture-RNA: 1 Affinity Capture-Western: 11 Co-crystal Structure: 2 Co-fractionation: 5 Co-purification: 7 PCA: 4 Reconstituted Complex: 2 Two-hybrid: 20
Genetic Interactions	Phenotypic Suppression: 1 Synthetic Growth Defect: 13 Synthetic Rescue: 19

Sequence Information

ChrIV:1261674 to 1262960 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1287	1261674..1262960	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002802

RPT3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RPT3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPT3]

1)	Finley D, et al. (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2)	Schnall R, et al. (1994) Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10(9):1141-55
3)	Glickman MH, et al. (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol 18(6):3149-62
4)	Glickman MH, et al. (1999) Functional analysis of the proteasome regulatory particle. Mol Biol Rep 26(1-2):21-8
5)	Rubin DM, et al. (1998) Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. EMBO J 17(17):4909-19
6)	Kimura Y, et al. (2003) N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome. Arch Biochem Biophys 409(2):341-8

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