RPT1/YKL145W Summary Help

RPT1 BASIC INFORMATION

Standard Name RPT1 1
Systematic Name YKL145W
Alias CIM5 2 , YTA3 3
Feature Type ORF, Verified
Description One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p (4, 5, 6, 7)
Name Description Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 1
GO Annotations All RPT1 GO evidence and references
    View Computational GO annotations for RPT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All RPT1 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
Interactions RPT1 All interactions details and references
295 total interaction(s) for 93 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 126
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 73
  • Co-fractionation: 3
  • Co-purification: 20
  • PCA: 6
  • Reconstituted Complex: 7
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 2
  • Synthetic Rescue: 38
Sequence Information
ChrXI:174218 to 175621 | ORF Map | GBrowse
This feature contains embedded feature(s): YKL145W-A
Gbrowse
Last Update Coordinates: 2004-02-13 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1404 174218..175621 2004-02-13 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001628

RPT1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for RPT1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPT1]

1) Finley D, et al.  (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2) Ghislain M, et al.  (1993) S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase. Nature 366(6453):358-62
3) Schnall R, et al.  (1994) Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10(9):1141-55
4) Takeuchi J and Toh-e A  (1999) Genetic evidence for interaction between components of the yeast 26S proteasome: combination of a mutation in RPN12 (a lid component gene) with mutations in RPT1 (an ATPase gene) causes synthetic lethality. Mol Gen Genet 262(1):145-53
5) Glickman MH, et al.  (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol 18(6):3149-62
6) Rubin DM, et al.  (1998) Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. EMBO J 17(17):4909-19
7) Morris MC, et al.  (2003) Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast. Nature 423(6943):1009-13