Standard Name	RPO41
Systematic Name	YFL036W
Feature Type	ORF, Verified
Description	Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation (1, 2, 3)
Name Description	RNA POlymerase

Chromosomal Location	ChrVI:58782 to 62837 | ORF Map | GBrowse

	View Computational GO annotations for RPO41
Molecular Function
Manually curated	DNA-directed RNA polymerase activity (IDA)
Biological Process
Manually curated	mitochondrial genome maintenance (IMP) transcription from mitochondrial promoter (IDA, IMP)
Cellular Component
Manually curated	mitochondrial DNA-directed RNA polymerase complex (IDA) mitochondrial matrix (IDA) mitochondrial nucleoid (IDA)
High-throughput	cytoplasm (IDA) mitochondrion (IDA)

Classical genetics
conditional	respiratory growth: absent
null	tellurium atom accumulation: decreased hyperosmotic stress resistance: decreased resistance to tellurite: increased
reduction of function	ROS accumulation: increased oxidative stress resistance: decreased mitochondrially-encoded protein accumulation: abnormal Tar1p-LacZ accumulation: decreased respiratory growth: decreased rate survival rate in stationary phase: decreased
Large-scale survey
null	glycogen accumulation: decreased polyphosphate accumulation: abnormal chitin deposition: increased competitive fitness: decreased dessication resistance: decreased filamentous growth: decreased invasive growth: absent mitochondrial morphology: abnormal resistance to farnesol: decreased resistance to streptomycin: decreased resistance to 2,4-dichlorophenol: decreased resistance to Calcofluor White: normal resistance to cycloheximide: decreased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased utilization of carbon source: absent utilization of carbon source: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	133 total interaction(s) for 115 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 2 Co-purification: 1 PCA: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 6 Negative Genetic: 74 Phenotypic Enhancement: 1 Positive Genetic: 10 Synthetic Growth Defect: 8 Synthetic Lethality: 10 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVI:58782 to 62837 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4056 58782..62837 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001858