Standard Name	RPN9 1
Systematic Name	YDR427W
Alias	NAS7 2
Feature Type	ORF, Verified
Description	Non-ATPase regulatory subunit of the 26S proteasome; similar to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia (3, 4, 5, 6)
Name Description	Regulatory Particle Non-ATPase 1

Chromosomal Location	ChrIV:1322205 to 1323386 | ORF Map | GBrowse

	View Computational GO annotations for RPN9
Molecular Function
Manually curated	structural molecule activity (IMP)
Biological Process
Manually curated	proteasome assembly (IMP) ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	cytosol (IDA) nucleus (IDA) proteasome regulatory particle, lid subcomplex (IDA) proteasome storage granule (IDA)

Classical genetics
null	cell cycle progression in metaphase: arrested heat sensitivity: increased oxidative stress resistance: increased vegetative growth: decreased viable
Large-scale survey
null	haploinsufficient inviable resistance to clioquinol: decreased vegetative growth: normal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	179 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 136 Affinity Capture-RNA: 1 Affinity Capture-Western: 20 Co-purification: 3 PCA: 3 Reconstituted Complex: 3 Two-hybrid: 8
Genetic Interactions	Dosage Lethality: 1 Phenotypic Suppression: 1 Synthetic Haploinsufficiency: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1322205 to 1323386 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1182 1322205..1323386 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002835