Standard Name	RPN7 1
Systematic Name	YPR108W
Feature Type	ORF, Verified
Description	Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits (2)
Name Description	Regulatory Particle Non-ATPase 1

Chromosomal Location	ChrXVI:742454 to 743743 | ORF Map | GBrowse

	View Computational GO annotations for RPN7
Molecular Function
Manually curated	structural molecule activity (IMP)
Biological Process
Manually curated	ubiquitin-dependent protein catabolic process (TAS)
Cellular Component
Manually curated	nucleus (IDA) proteasome regulatory particle, lid subcomplex (IDA)

Classical genetics
conditional	cell cycle progression through the G2/M phase transition: abnormal cell size: increased heat sensitivity: increased polyubiquinated proteins accumulation: increased polyubiquitinated proteins accumulation: increased Pds1p accumulation: increased Clb2p accumulation: increased
null	hydrostatic pressure resistance: decreased
Large-scale survey
null	cell size: increased inviable resistance to clioquinol: decreased
reduction of function	competitive fitness: increased telomere length: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	184 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-MS: 104 Affinity Capture-RNA: 2 Affinity Capture-Western: 28 Co-purification: 3 Reconstituted Complex: 4 Two-hybrid: 8
Genetic Interactions	Negative Genetic: 22 Positive Genetic: 10 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:742454 to 743743 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1290 742454..743743 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006312