Standard Name	RPN5 1
Systematic Name	YDL147W
Alias	NAS5
Feature Type	ORF, Verified
Description	Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein (2, 3, 4)
Name Description	Regulatory Particle Non-ATPase 1

Chromosomal Location	ChrIV:190924 to 192261 | ORF Map | GBrowse

	View Computational GO annotations for RPN5
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cullin deneddylation (IMP) ubiquitin-dependent protein catabolic process (TAS)
Cellular Component
Manually curated	proteasome complex (IDA) proteasome regulatory particle, lid subcomplex (IDA) proteasome storage granule (IDA) signalosome (IDA)

Classical genetics
conditional	colony sectoring: increased resistance to hydroxyurea: decreased resistance to bleomycin: decreased
Large-scale survey
conditional	colony sectoring: increased heat sensitivity: increased
null	heat sensitivity: increased inviable resistance to clioquinol: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased toxin resistance: decreased
reduction of function	competitive fitness: increased telomere length: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	324 total interaction(s) for 99 unique genes/features.
Physical Interactions	Affinity Capture-MS: 238 Affinity Capture-RNA: 3 Affinity Capture-Western: 22 Co-purification: 7 PCA: 4 Reconstituted Complex: 5 Two-hybrid: 14
Genetic Interactions	Negative Genetic: 22 Positive Genetic: 6 Synthetic Growth Defect: 1 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:190924 to 192261 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1338 190924..192261 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002306