RPM2/YML091C Summary Help

Standard Name RPM2 1
Systematic Name YML091C
Feature Type ORF, Verified
Description Protein subunit of mitochondrial RNase P; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus (2, 3, 4, 5, 6, 7)
Name Description RNase P Mitochondrial 1
Chromosomal Location
ChrXIII:90731 to 87123 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All RPM2 GO evidence and references
  View Computational GO annotations for RPM2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Classical genetics
reduction of function
Large-scale survey
reduction of function
47 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 1
  • Reconstituted Complex: 14
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 6
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 1,202
Molecular Weight (Da) 139,347
Isoelectric Point (pI) 6.73
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIII:90731 to 87123 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..3609 90731..87123 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004556
References cited on this page View Complete Literature Guide for RPM2
1) Morales MJ, et al.  (1992) A 105-kDa protein is required for yeast mitochondrial RNase P activity. Proc Natl Acad Sci U S A 89(20):9875-9
2) Stribinskis V, et al.  (1996) Yeast mitochondrial RNase P RNA synthesis is altered in an RNase P protein subunit mutant: insights into the biogenesis of a mitochondrial RNA-processing enzyme. Mol Cell Biol 16(7):3429-36
3) Stribinskis V, et al.  (2001) Rpm2, the protein subunit of mitochondrial RNase P in Saccharomyces cerevisiae, also has a role in the translation of mitochondrially encoded subunits of cytochrome c oxidase. Genetics 158(2):573-85
4) Stribinskis V, et al.  (2001) Rpm2p: separate domains promote tRNA and Rpm1r maturation in Saccharomyces cerevisiae mitochondria. Nucleic Acids Res 29(17):3631-7
5) Hollingsworth MJ and Martin NC  (1986) RNase P activity in the mitochondria of Saccharomyces cerevisiae depends on both mitochondrion and nucleus-encoded components. Mol Cell Biol 6(4):1058-64
6) Stribinskis V, et al.  (2005) Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus. Mol Cell Biol 25(15):6546-58
7) Stribinskis V and Ramos KS  (2007) Rpm2p, a protein subunit of mitochondrial RNase P, physically and genetically interacts with cytoplasmic processing bodies. Nucleic Acids Res 35(4):1301-11