ROD1/YOR018W Summary Help

Standard Name ROD1 1
Systematic Name YOR018W
Alias ART4 2
Feature Type ORF, Verified
Description Alpha-arrestin family member; activation through a switch in its modification state relays glucose signaling to transporter endocytosis; contributes to desensitization of agonist-occupied Ste2p by Rsp5p-dependent internalization and to recovery from pheromone induced G1 arrest; interacts with ubiquitin ligase Rsp5p via its 2 PY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7)
Name Description Resistance to O-Dinitrobenzene 1
Chromosomal Location
ChrXV:364369 to 366882 | ORF Map | GBrowse
Gene Ontology Annotations All ROD1 GO evidence and references
  View Computational GO annotations for ROD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Classical genetics
reduction of function
Large-scale survey
60 total interaction(s) for 38 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 6
  • Biochemical Activity: 7
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 9
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 2
  • Positive Genetic: 3
  • Synthetic Growth Defect: 3

Expression Summary
Length (a.a.) 837
Molecular Weight (Da) 92,348
Isoelectric Point (pI) 9.41
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:364369 to 366882 | ORF Map | GBrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2514 364369..366882 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005544
References cited on this page View Complete Literature Guide for ROD1
1) Wu AL, et al.  (1996) ROD1, a novel gene conferring multiple resistance phenotypes in Saccharomyces cerevisiae. J Biol Chem 271(6):2914-20
2) Lin CH, et al.  (2008) Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell 135(4):714-25
3) Andoh T, et al.  (2002) PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance. FEBS Lett 525(1-3):131-4
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Becuwe M, et al.  (2012) A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis. J Cell Biol 196(2):247-59
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Alvaro CG, et al.  (2014) Specific alpha-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein coupled receptor Ste2. Mol Cell Biol ()